Eotaxin 3

Alternative Names: C-C motif chemokine 26, CCL26, Small-inducible cytokine A26, SCYA26, Eotaxin-3, Macrophage inflammatory protein 4-alpha, MIP-4-alpha, MIP-4a, MIP-4alpha, Thymic stroma chemokine-1, TSC-1, CC chemokine IMAC, IMAC, MGC126714.

Eotaxin-3 (CCL26) is a small cytokine belonging to the CC chemokine family, also known as TARC. It is primarily produced by alveolar epithelial cells and plays a role in regulating CCR3 receptors and other eotaxins. Eotaxin-3 is involved in immunoregulatory and inflammatory processes, specifically binding and stimulating chemotaxis in T cells through interaction with the CCR4 receptor. It exhibits chemotactic activity for eosinophils and basophils and may be involved in eosinophil accumulation in atopic diseases. Overexpression of Eotaxin-3 is seen in eosinophilic esophagitis and correlates with disease severity. The gene for Eotaxin-3 is located on chromosome 7.

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  • Sku: PSB-chm-362-10µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

Recombinant Human Eotaxin-3 (CCL26) is a chemokine protein belonging to the CC subfamily. It plays a role in the recruitment of eosinophils, basophils, and T cells to sites of inflammation. With a molecular weight of approximately 8.9 kDa, this protein is involved in the regulation of immune responses and inflammatory processes. Recombinant Human Eotaxin-3 (CCL26) is commonly used in research studies to investigate its role in various diseases and conditions.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 97.0 % by SDS-PAGE
Activity
 Determined by its ability to chemoattract BaF3 mouse pro-B cells transfected with mouse CCR3. The ED50 for this effect is typically 0.1-1.0 μg/ml.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH 7.4.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

TRGSDISKTC CFQYSHKPLP WTWVRSYEFT SNSCSQRAVI FTTKRGKKVC THPRKKWVQK YISLLKTPKQ L.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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Eotaxin 3
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