Endoglin

Alternative Names: CD105, ENG, END, Endoglin, ORW, HHT1, ORW1, FLJ41744

Endoglin is a membrane glycoprotein involved in the TGF beta receptor complex. It is a homodimer of 180 kDA with disulfide links and found on various cell types including endothelial cells, activated macrophages, fibroblasts, and smooth muscle cells. Endoglin is responsible for binding TGF-beta1, TGF-beta3, activin-A, BMP-2, and BMP-7. In addition to TGF-beta signaling, endoglin may play a role in cell morphology, migration, cytoskeletal organization, cardiovascular system development, and vascular remodeling. Its expression is regulated during heart development, and experimental mice lacking the endoglin gene display cardiovascular abnormalities leading to death.

Skip to product information
  • Sku: PSB-cyt-525-2µg
  • Vendor: ProSpec-Tany
$175.00 USD
 per 
Shipping calculated at checkout.

Contact us directly for international purchases.

Title

Product Details

Product Description

Recombinant Human Endoglin is a glycoprotein belonging to the TGF-beta receptor family, specifically the type III subfamily. It is involved in the regulation of angiogenesis and plays a role in cardiovascular development. With a molecular weight of approximately 65-70 kDa, Recombinant Human Endoglin is commonly used in research studies to investigate its function and potential therapeutic applications in various diseases.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Dimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation Endoglin solutionin 50mM Tris-Acetate, pH-7.5, 1mM EDTA and 20% Glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

Check Uniprot Link

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

View full details

Endoglin

SUBHEADING

Recently viewed products