ENA 78

Alternative Names: Small inducible cytokine B5, SCYB5, CXCL5, chemokine (C-X-C motif) ligand 5, Epithelial-derived neutrophil-activating protein 78, Neutrophil-activating peptide ENA-78, ENA-78(1-78)

CXCL5, also known as ENA-78, is a small cytokine that belongs to the CXC chemokine family. It is produced in response to inflammatory cytokines, particularly interleukin-1 and tumor necrosis factor-alpha, and has been observed in eosinophils. Its effects include stimulating neutrophil chemotaxis and possessing angiogenic properties by interacting with the CXCR2 receptor. The gene for CXCL5 is located on human chromosome 4 and has been implicated in connective tissue remodelling.

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  • Sku: PSB-chm-331-5µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

Recombinant Human Epithelial Neutrophil-Activating Protein 78 (CXCL5) is a member of the CXC chemokine family, known for its role in the recruitment and activation of neutrophils in inflammatory responses. With a molecular weight of approximately 8 kDa, CXCL5 plays a key role in the regulation of immune cell migration and activation within the body. Its ability to induce chemotaxis in neutrophils makes it a crucial player in the body's immune response to infection and inflammation.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 The biological activity was determined by measuring the dose dependent mobilization of intracellular calcium (calcium flux) with human neutrophils. Significant calcium mobilization is observed with 100ng/mL (corresponding to a Specific Activity of 10,000IU/mg)  of recombinant human ENA-78. The biological activity was determined by measuring the dose dependent mobilization of intracellular calcium (calcium flux) with human neutrophils. Significant calcium mobilization is observed with 100ng/mL (corresponding to a Specific Activity of 10,000IU/mg)  of recombinant human ENA-78.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Oligomer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation The CXCL5 was lyophilized from a concentrated (1mg/ml) solution in water containing no additives.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

The sequence of the first five N-terminal amino acids was determined and was found to be, Ala- Ala -Val-Leu-Arg.

Storage Instruction

Lyophilized ENA78 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL5 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized ENA-78 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available
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ENA 78
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