EIF4H

Alternative Names: Eukaryotic translation initiation factor 4H, EIF4H, eIF-4H, Williams-Beuren syndrome chromosomal region 1 protein, WBSCR1, KIAA0038, WSCR1.

The protein EIF4H plays a role in initiating protein synthesis by promoting the use of mRNA. It is found in the perinuclear region of the cytoplasm and exists in two isoforms, short and long. EIF4H stimulates the ATP hydrolysis process carried out by EIF4A and EIF4B. Defects in the EIF4H gene have been associated with Williams-Beuren syndrome (WBS), a rare disorder that affects cardiovascular and musculo-skeletal development. WBS is caused by the deletion of genes in the 7q11.23 region.

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  • Sku: PSB-pro-1114-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

Recombinant Human Eukaryotic Translation Initiation Factor 4H (eIF4H) is a protein that plays a significant role in the initiation of translation, a crucial step in protein synthesis. Belonging to the eukaryotic translation initiation factor family, eIF4H acts as a regulator, facilitating the assembly of the eIF4F complex, which is essential for the recruitment of ribosomes to mRNA. With a molecular weight of approximately X kDa, eIF4H's involvement in translation initiation underscores its importance in cellular processes. Understanding the functions and mechanisms of eIF4H can provide valuable insights into protein synthesis regulation and its potential implications in various biological contexts.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 29.9 kDa
Structure Monomer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation EIF4H protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 50% glycerol and 2mM DTT.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSHMADFDT YDDRAYSSFG GGRGSRGSAG GHGSRSQKEL PTEPPYTAYV GNLPFNTVQG DIDAIFKDLS IRSVRLVRDK DTDKFKGFCY VEFDEVDSLK EALTYDGALL GDRSLRVDIA EGRKQDKGGF GFRKGGPDDR GMGSSRESRG GWDSRDDFNS GFRDDFLGGR GGSRPGDRRT GPPMGSRFRD GPPLRGSNMD FREPTEEERA QRPRLQLKPR TVATPLNQVA NPNSAIFGGA RPREEVVQKE QE.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
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References

Not Available
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EIF4H
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