EIF4EBP2

Alternative Names: Not Available

CD47 is an adhesion receptor for THBS1 on platelets and is involved in cell adhesions. It also plays a role in regulating integrins. CD47 is important for memory formation and synaptic plasticity in the hippocampus. Additionally, CD47 acts as a receptor for SIRPA, preventing maturation of immature dendritic cells and inhibiting cytokine production by mature dendritic cells. CD47 helps prevent premature elimination of red blood cells and is associated with changes in membrane permeability following virus infection.

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  • Sku: PSB-pro-176-5µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human Eukaryotic Translation Initiation Factor 4E-Binding Protein 2 (4E-BP2) is a member of the eukaryotic translation initiation factor 4E-binding protein family. It plays a significant role in regulating protein synthesis by binding to eukaryotic translation initiation factor 4E (eIF4E), thereby inhibiting its interaction with the mRNA cap structure. With a molecular weight of approximately X kDa, 4E-BP2 serves as a modulator of translation initiation, controlling the availability of eIF4E for mRNA binding. This protein's involvement in translation regulation makes it a subject of interest in various research fields, including cellular signaling pathways and protein synthesis mechanisms.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System Sf9 - Insect cells
Purity 95% by SDS-PAGE
Activity
Determined by the binding ability in functional ELISA with Human SIRP alpha/CD172a (cat# pro-2080). The ED50 range ≤ 100 ng/ml.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
40.9 kDa
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation CD47 protein solution (0.5mg/ml) containing Phosphate Buffered Saline (pH 7.4) and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

QLLFNKTKSV EFTFCNDTVV IPCFVTNMEA QNTTEVYVKW KFKGRDIYTF DGALNKSTVP TDFSSAKIEV SQLLKGDASL KMDKSDAVSH TGNYTCEVTE LTREGETIIE LKYRVVSWFS PNELEPKSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDPEVKFNWYVDG VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL PPSRDELTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGKHHHH HH.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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EIF4EBP2

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