EIF4EBP1

Alternative Names: 4E-BP1, BP-1, 4EBP1, EIF4EBP1, eIF4E-binding protein 1, Eukaryotic translation initiation factor 4E-binding protein 1, MGC4316, PHAS-I

EIF4EBP1 is a translation repressor protein that regulates the activity of eIF4E. It prevents the assembly of eIF4E into the eIF4F complex and plays a role in mediating the regulation of protein translation. This regulation is influenced by hormones, growth factors, and other stimuli that signal through the MAP kinase and mTORC1 pathways. EIF4EBP1 is phosphorylated in response to various signals, including UV irradiation, leading to its dissociation from eIF4E and the activation of mRNA translation. The C-terminus of EIF4EBP1 contains domains that control its function and phosphorylation. Furthermore, EIF4EBP1 is involved in the progression of breast neoplasms through cell signaling.

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  • Sku: PSB-pro-532-10µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Eukaryotic Translation Initiation Factor 4E-Binding Protein 1 (4E-BP1) is a protein that belongs to the eukaryotic translation initiation factor family. With a molecular weight of approximately 20 kDa, 4E-BP1 plays a crucial role in regulating protein synthesis by binding to eukaryotic translation initiation factor 4E (eIF4E). This interaction inhibits the assembly of the eIF4F complex, which is essential for cap-dependent translation initiation. By modulating translation initiation, 4E-BP1 contributes to the control of cellular growth, proliferation, and survival.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 14.7 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The EIF4EBP1 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH8.0) and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MSGGSSCSQT PSRAIPATRR VVLGDGVQLP PGDYSTTPGG TLFSTTPGGT RIIYDRKFLM ECRNSPVTKT PPRDLPTIPG VTSPSSDEPP MEASQSHLRN SPEDKRAGGE ESQFEMDI.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
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References

Not Available
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EIF4EBP1
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