EIF4E

Alternative Names: CBP, EIF4F, EIF4E1, EIF4EL1

EIF4E is an eukaryotic initiation factor that plays a pivotal role in the regulation of translation in early embryos. It specifically recognizes and binds to a specific structure called the 7 methyl GTP cap found in eukaryotic mRNAs. By doing so, EIF4E controls the initiation of translation. Additionally, EIF4E facilitates ribosome binding by unwinding the secondary structures present in mRNA molecules.

Skip to product information
  • Sku: PSB-pro-530-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
 per 
Shipping calculated at checkout.

Contact us directly for international purchases.

Title

Product Details

Product Description

Recombinant Human Eukaryotic Translation Initiation Factor 4E (eIF4E) is a protein that plays a vital role in the initiation of protein synthesis in eukaryotic cells. Belonging to the eIF4E family, this protein is responsible for binding to the mRNA cap structure, facilitating the recruitment of other translation initiation factors and ribosomes. With a molecular weight of approximately 25 kDa, eIF4E acts as a key regulator in the control of gene expression, enabling efficient translation of mRNA into functional proteins. Its significance lies in its ability to modulate cellular processes, making it an important target for therapeutic interventions and further exploration in various biological contexts.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 85.0% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation The EIF4E 0.5mg/ml protein solution contains 20mM Tris-HCl, pH-8, and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MATVEPETTP TPNPPTTEEE KTESNQEVAN PEHYIKHPLQ NRWALWFFKN DKSKTWQANL RLISKFDTVEDFWALYNHIQ LSSNLMPGCD YSLFKDGIEP MWEDEKNKRG GRWLITLNKQ QRRSDLDRFW LETLLCLIGE SFDDYSDDVC GAVVNVRAKG DKIAIWTTEC ENREAVTHIG RVYKERLGLP PKIVIGYQSH ADTATKSGST TKNRFVV.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

View full details

EIF4E

SUBHEADING

Recently viewed products