EDA2R Sf9

Alternative Names: Tumor necrosis factor receptor superfamily member 27, Tumor Necrosis Factor Receptor Superfamily Member 27, TNFRSF27, X-linked ectodysplasin-A2 receptor, X-Linked Ectodysplasin-A2 Receptor, XEDAR, EDA-A2 receptor, Ectodysplasin A2 Receptor, EDA-A2 Receptor, EDA-A2 receptor, Ectodysplasin A2 Isoform Receptor, EDA-A2R, EDAA2R, Tumor Necrosis Factor Receptor Superfamily Member XEDAR.

EDA2R activates the NF-kappa-B and JNK pathways by binding to TRAF3 and TRAF6. Mutations in EDA lead to a clinical syndrome characterized by hair loss, loss of sweat glands, and loss of teeth. EDA2R specifically binds to the EDA-A2 isoform. This protein is a type III transmembrane protein of the TNFR superfamily, with 3 cysteine-rich repeats and a single transmembrane domain but lacks an N-terminal signal peptide. Splicing variants have been found for this gene. Diseases associated with EDA2R include ectodermal dysplasia 1, hypohidrotic, x-linked, and hypohidrotic ectodermal dysplasia.

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  • Sku: PSB-pro-2399-2µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Ectodysplasin A2 Receptor, Sf9 is a protein that belongs to the tumor necrosis factor receptor superfamily. It plays a significant role in the development of ectodermal appendages, such as hair, teeth, and sweat glands. With a molecular weight of approximately X kilodaltons, this receptor is involved in the activation of the NF-κB signaling pathway, which regulates various cellular processes. Understanding the biochemical properties and functions of Recombinant Human Ectodysplasin A2 Receptor, Sf9 is crucial for advancing research in the field of ectodermal development and related disorders.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System Sf9 - Baculovirus cells
Purity 90% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 42.5 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation EDA2R protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4), 20% glycerol and 1mM DTT.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

ADPMDCQENE YWDQWGRCVT CQRCGPGQEL SKDCGYGEGG DAYCTACPPR RYKSSWGHHR CQSCITCAVI NRVQKVNCTA TSNAVCGDCL PRFYRKTRIG GLQDQECIPC TKQTPTSEVQ CAFQLSLVEA DAPTVPPQEA TLEPKSCDKT HTCPPCPAPE LLGGPSVFLF PPKPKDTLMI SRTPEVTCVV VDVSHEDPEV KFNWYVDGVE VHNAKTKPRE EQYNSTYRVV SVLTVLHQDW LNGKEYKCKV SNKALPAPIE KTISKAKGQP REPQVYTLPP SRDELTKNQV SLTCLVKGFY PSDIAVEWES NGQPENNYKT TPPVLDSDGS FFLYSKLTVD KSRWQQGNVF SCSVMHEALH NHYTQKSLSL SPGKHHHHHH.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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EDA2R Sf9
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