EBAG9

Alternative Names: EB9, EBAG9, PDAF, RCAS1, Receptor-binding cancer antigen expressed on SiSo cells, Cancer-associated surface antigen RCAS1, Estrogen receptor-binding fragment-associated gene 9 protein.

EBAG9 is a transmembrane protein found primarily in the Golgi. It is a tumor-associated antigen that is commonly present in advanced breast and prostate cancers. While EBAG9 inhibits the growth of receptor-binding cells and triggers apoptosis of immune cells, cancer cells can use this protein to evade immune surveillance. Therefore, detecting EBAG9 expression can be used as a negative prognosis indicator. EBAG9 also promotes the progression of bladder cancer. In rheumatoid arthritis, the lack of EBAG9 leads to immune attack and subsequent apoptosis of synovial lining cells. Additionally, EBAG9 is involved in regulating exocytosis processes. It is also linked to the progression of oral squamous cell carcinoma and has a specific role in early-stage breast carcinogenesis.

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  • Sku: PSB-pro-343-10µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

Recombinant Human Estrogen Receptor Binding Site Associated Antigen 9 (ERBIN) is a protein that plays a significant role in cellular processes. Belonging to the PDZ domain-containing family, ERBIN is involved in protein-protein interactions and acts as a scaffold for various signaling molecules. With a molecular weight of approximately X kDa, ERBIN is crucial for the proper functioning of estrogen receptor signaling pathways. Its role in cellular processes makes ERBIN an important target for studying the molecular mechanisms underlying hormone-related diseases and potential therapeutic interventions.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The EBAG9 protein solution contains 20mM Tris-HCl pH-8, 1mM DTT, 2mM EDTA and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MRSGRGRKLS GDQITLPTTV DYSSVPKQTD VEEWTSWDED APTSVKIEGG NGNVATQQNS LEQLEPDYFK DMTPTIRKTQ KIVIKKREPL NFGIPDGSTG FSSRLAATQD LPFIHQSSEL GDLDTWQENT NAWEEEEDAA WQAEEVLRQQ KLADREKRAA EQQRKKMEKE AQRLMKKEQN KIGVKLS.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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EBAG9
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