DYNLL2

Alternative Names: ADAM10, ADAM metallopeptidase domain 10, A disintegrin and metalloproteinase domain 10, Mammalian disintegrin-metalloprotease, Kuzbanian protein homolog, CDw156, CD156c, HsT18717, Kuz, MADM

ADAM10 is a member of the ADAM family of cell surface proteins. These proteins have a unique structure that includes both adhesive and protease domains. ADAM10 plays a role in cleaving various proteins, such as TNF-alpha and E-cadherin. For example, it cleaves the membrane-bound precursor of TNF-alpha to produce its mature soluble form by cleaving at position 76-ala-|-val-77. ADAM10 is also responsible for the proteolytic release of other cell-surface proteins, including heparin-binding epidermal growth-like factor and ephrin-a2. It is involved in the cleavage of amyloid precursor protein as both a constitutive and regulated alpha-secretase. ADAM10 is also involved in the normal cleavage of cellular prion protein, the adhesion molecule L1, and in the release of membrane vesicles, suggesting a vesicle-based protease activity. Additionally, ADAM10 controls the proteolytic processing of notch and mediates lateral inhibition during neurogenesis.

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  • Sku: PSB-pro-235-5µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

Recombinant Human Dynein Light Chain LC8 Type-2 is a protein that belongs to the dynein light chain family. With a weight of approximately 8.5 kDa, it plays a significant role in various cellular processes. This protein is involved in the regulation of dynein motor activity, which is crucial for intracellular transport and microtubule organization. Recombinant Human Dynein Light Chain LC8 Type-2 is widely studied for its functional implications in cellular dynamics and its potential therapeutic applications.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System Sf9 - Baculovirus cells
Purity 85.0% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 51.6 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation ADAM10 protein solution (0.5mg/ml) containing Phosphate Buffered Saline (pH 7.4) and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

TTSAEKNTCQ LYIQTDHLFF KYYGTREAVI AQISSHVKAI DTIYQTTDFS GIRNISFMVK RIRINTTADE KDPTNPFRFP NIGVEKFLEL NSEQNHDDYC LAYVFTDRDF DDGVLGLAWV GAPSGSSGGI CEKSKLYSDG KKKSLNTGII TVQNYGSHVP PKVSHITFAH EVGHNFGSPH DSGTECTPGE SKNLGQKENG NYIMYARATS GDKLNNNKFS LCSIRNISQV LEKKRNNCFV ESGQPICGNG MVEQGEECDC GYSDQCKDEC CFDANQPEGR KCKLKPGKQC SPSQGPCCTA QCAFKSKSEK CRDDSDCARE GICNGFTALC PASDPKPNFT DCNRHTQVCI NGQCAGSICE KYGLEECTCA SSDGKDDKEL CHVCCMKKMD PSTCASTGSV QWSRHFSGRT ITLQPGSPCN DFRGYCDVFM RCRLVDADGP LARLKKAIFS PELYENIAEL EHHHHHH

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
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References

Not Available
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DYNLL2
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