DUSP26

Alternative Names: Dual specificity protein phosphatase 26, DUSP26, DUSP24, Dual specificity phosphatase SKRP3, SKRP3, Low-molecular-mass dual-specificity phosphatase 4, LDP4, LDP-4, Mitogen-activated protein kinase phosphatase 8, MAP kinase phosphatase 8, MKP8, MKP-8, Novel amplified gene in thyroid anaplastic cancer, NATA1, Dual specificity phosphatase 26 (putative).

DUSP26 functions as a regulator in anaplastic thyroid cancer cells by inhibiting the MAP kinase p38 to prevent apoptosis and activating MAP kinase p38 and c-Jun N-terminal kinase. Additionally, DUSP26 deactivates MAPK1 and MAPK3, resulting in the decreased DNA-binding activity of heat shock factor protein 4.

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  • Sku: PSB-enz-747-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

Recombinant Human Dual Specificity Phosphatase 26 is a member of the protein tyrosine phosphatase family, specifically belonging to the dual specificity phosphatase subfamily. This enzyme plays a role in the regulation of cell growth, differentiation, and apoptosis by dephosphorylating both phosphotyrosine and phosphoserine/threonine residues on target proteins. Recombinant Human Dual Specificity Phosphatase 26 has a molecular weight of approximately 33 kDa, making it a key player in cellular signaling pathways.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 85.0% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 26.3 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The DUSP26 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 0.4M Urea.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSMCPGNWL WASMTFMARF SRSSSRSPVR TRGTLEEMPT VQHPFLNVFE LERLLYTGKT ACNHADEVWP GLYLGDQDMA NNRRELRRLG ITHVLNASHS RWRGTPEAYE GLGIRYLGVE AHDSPAFDMS IHFQTAADFI HRALSQPGGK ILVHCAVGVS RSATLVLAYL MLYHHLTLVE AIKKVKDHRG IIPNRGFLRQ LLALDRRLRQ GLEA.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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DUSP26
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