DUSP21

Alternative Names: EC 3.1.3.16, EC 3.1.3.48, Dual specificity phosphatase 21, Low molecular weight dual specificity phosphatase 21, LMW-DSP21, BJ-HCC-26 tumor antigen

DUSP21, a member of the protein-tyrosine phosphatase family, functions to inactivate target kinases by dephosphorylating phosphoserine/threonine and phosphotyrosine residues. It has been found to preferentially dephosphorylate single and diphosphorylated synthetic MAPK peptides, with a preference for phosphotyrosine and diphosphorylated forms over phosphothreonine. DUSP21 is uniquely expressed in the testis, where dephosphorylated phosphotyrosine residues in MAPK peptides are present.

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  • Sku: PSB-enz-239-2µg
  • Vendor: ProSpec-Tany
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Product Details

Product Description

Recombinant Human Dual Specificity Phosphatase 21 is a member of the protein tyrosine phosphatase family, specifically belonging to the dual-specificity phosphatase subfamily. It is a phosphatase enzyme that plays a role in regulating various cellular processes by dephosphorylating both phosphotyrosine and phosphoserine/threonine residues on target proteins. With a molecular weight of approximately 40 kDa, Recombinant Human Dual Specificity Phosphatase 21 is involved in the modulation of signaling pathways and cellular functions through its enzymatic activity.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 24.1 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The DUSP21 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 200mM NaCl, 2mM DTT and 20% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSHMTASAS SFSSSQGVQQ PSIYSFSQIT RSLFLSNGVA ANDKLLLSSN RITAIVNASV EVVNVFFEGI QYIKVPVTDA RDSRLYDFFD PIADLIHTID MRQGRTLLHC MAGVSRSASL CLAYLMKYHS MSLLDAHTWT KSRRPIIRPN NGFWEQLINY EFKLFNNNTV RMINSPVGNI PDIYEKDLRM MISM

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
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References

Not Available
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DUSP21
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