DUSP19

Alternative Names: Protein phosphatase, Dual specificity protein phosphatase 19, DUSP19, Dual specificity phosphatase TS-DSP1, TS-DSP1, Low molecular weight dual specificity phosphatase 3, LMW-DSP3, LMWDSP3, Low molecular weight dual specificity phosphatase 3, Stress-activated protein kinase pathway-regulating phosphatase 1, SAPK pathway-regulating phosphatase 1, SKRP1, DUSP17.

DUSPs are enzymes that can remove phosphate groups from both tyrosine and serine/threonine residues, influencing important cellular signaling pathways. DUSP19 is a member of the dual specificity protein phosphatase subfamily, working as a stress-activated protein kinase pathway regulator. It has a unique C-terminal catalytic domain and does not possess the CH2 domain characteristic of MKP class DUSPs.

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  • Sku: PSB-enz-201-2µg
  • Vendor: ProSpec-Tany
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UniProt Listing
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Product Details

Product Description

Recombinant Human Dual Specificity Phosphatase 19 (DUSP19) is a member of the dual specificity phosphatase family, which plays a critical role in regulating various cellular processes by dephosphorylating both phosphotyrosine and phosphoserine/threonine residues on proteins. DUSP19 has a molecular weight of approximately 45 kDa and is involved in the regulation of mitogen-activated protein kinase (MAPK) signaling pathways. This enzyme is a promising target for therapeutic interventions in diseases characterized by dysregulated MAPK signaling.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 19.4 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The DUSP19 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 30% glycerol and 0.1M NaCl.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSQVGVIKP WLLLGSQDAA HDLDTLKKNK VTHILNVAYG VENAFLSDFT YKSISILDLP ETNILSYFPE CFEFIEEAKR KDGVVLVHCN AGVSRAAAIV IGFLMNSEQT SFTSAFSLVK NARPSICPNS GFMEQLRTYQ EGKESNKCDR IQENSS.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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DUSP19
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