DSTN

Alternative Names: Destrin, ACTDP, ADF, bA462D18.2 (destrin (actin depolymerizing factor ADF) (ACTDP)), DSN, Destrin (actin depolymerizing factor),

Actin depolymerizing factor (Destrin/DSTN) is a member of the ADF/Cofilin/destrin protein superfamily that can quickly break down F-Actin molecules. The ADF protein family helps to speed up the replacement of actin in living organisms. Destrin is a small actin-binding protein that is sensitive to phosphoinositides and can break down actin-filaments in the lab. DSTN works independently of pH levels. DSTN is found in various epithelial and endothelial cells, but is rarely found in adult mouse heart and skeletal muscle cells. Destrin is 71% similar in sequence to Cofilin, but the two proteins differ in their interaction with Actin.

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  • Sku: PSB-pro-1137-5µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

Recombinant Human Destrin is a protein that belongs to the actin-depolymerizing factor (ADF)/cofilin family. With a molecular weight of approximately 19 kilodaltons (kDa), this protein plays a significant role in regulating actin dynamics within cells. Recombinant Human Destrin is synthesized using recombinant DNA technology, allowing for its production in large quantities for research purposes. Its precise control over actin filament turnover makes it a valuable tool for studying cellular processes such as cell migration, cytoskeletal rearrangement, and cell division.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Monomer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The DSTN solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 1mM DTT and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MASGVQVADE VCRIFYDMKV RKCSTPEEIK KRKKAVIFCL SADKKCIIVE EGKEILVGDV GVTITDPFKH FVGMLPEKDC RYALYDASFE TKESRKEELM FFLWAPELAP LKSKMIYASS KDAIKKKFQG IKHECQANGP EDLNRACIAE KLGGSLIVAF EGCPVLEHHH HHH

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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DSTN
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