DR1

Alternative Names: Negative cofactor 2-beta, NC2-BETA, NC2.

DR1 is a phosphoprotein that restrains both basal and activated transcription. In vivo phosphorylation of DR1 modifies its interaction with TBP. DR1 contains a histone fold motif at the amino terminus, a TBP-binding domain, and a region abundant in glutamine and alanine. By specifically inhibiting polymerases II and III, DR1 changes the balance of transcriptional output in favor of polymerase I.

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  • Sku: PSB-pro-542-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Title

Product Details

Product Description

Recombinant Human Down-Regulator of Transcription 1 (rhDR1) is a protein that belongs to the family of transcriptional regulators. With a weight of approximately X kilodaltons, rhDR1 plays a significant role in modulating gene expression by binding to specific DNA sequences and inhibiting the transcriptional activity of target genes. This protein's functionality is of immense interest in various biological and medical research fields due to its potential implications in understanding disease mechanisms and developing therapeutic interventions.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 85.0% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation DR1 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 0.1mM PMSF, 0.1M NaCl & 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MASSSGNDDD LTIPRAAINK MIKETLPNVR VANDARELVV NCCTEFIHLI SSEANEICNK SEKKTISPEH VIQALESLGF GSYISEVKEV LQECKTVALK RRKASSRLEN LGIPEEELLR QQQELFAKAR QQQAELAQQE WLQMQQAAQQ AQLAAASASA NQAGSSQDE EDDDDI.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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DR1

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