DNAJB8

Alternative Names: DnaJ homolog subfamily B member 8, DJ6, DNAJB8.

DNAJB8, a member of the DNAJ/HSP40 protein family, has shown great potential in suppressing the aggregation and toxicity of disease-associated polyglutamine proteins. This protein undergoes (de)acetylation at two specific lysine residues located at its C-terminal. Although these residues do not directly interact with substrate binding, they play a crucial role in preventing protein aggregation. Furthermore, DNAJB8 has been implicated as a cancer-testis antigen and a cancer stem-like cell antigen in renal cell carcinoma.

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  • Sku: PSB-hsp-050-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human DnaJ (Hsp40) Homolog, Subfamily B, Member 8, also known as DNAJB8, is a protein belonging to the DnaJ/Hsp40 family. With a molecular weight of approximately X kDa, DNAJB8 plays a role in protein folding, assembly, and degradation processes within the cell. This protein is involved in various cellular functions, including chaperoning, stress response, and regulation of protein-protein interactions. Understanding the functions and mechanisms of DNAJB8 can provide valuable insights into cellular processes and potential therapeutic targets.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 27.8 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The DNAJB8 solution (0.25mg/ml) 20mM Tris-HCl buffer (pH8.0), 40% glycerol, 0.15M NaCl and 1mM DTT.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MANYYEVLGV QASASPEDIK KAYRKLALRW HPDKNPDNKE EAEKKFKLVS EAYEVLSDSK KRSLYDRAGC DSWRAGGGAS TPYHSPFDTG YTFRNPEDIF REFFGGLDPF SFEFWDSPFN SDRGGRGHGL RGAFSAGFGE FPAFMEAFSS FNMLGCSGGS HTTFSSTSFG GSSSGSSGFK SVMSSTEMIN GHKVTTKRIV ENGQERVEVE EDGQLKSVTV NGKEQLKWMD SK.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
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References

Not Available
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DNAJB8
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