DKK3 Sf9

Alternative Names: Dickkopf 3 homolog (Xenopus laevis), dickkopf-related protein 3, Dkk-3, regulated in glioma, REIC, RIG, RIG-like 5-6, RIG-like 7-1.

Dickkopf-related protein 3 (DKK3) is a member of the DKK protein family that includes Dkk-1, Dkk-2, Dkk-3, and Dkk-4. DKK3 is a glycoprotein composed of 350 amino acids, with an N-terminal signal peptide and two cysteine-rich domains separated by a 12 amino acid linker region. Its main role is in embryonic development, where it inhibits the WNT signaling pathway. DKK3 gene expression is reduced in various cancer cell lines and it has been suggested that DKK3 may function as a tumor suppressor gene.

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  • Sku: PSB-pro-2391-1µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human Dickkopf-Related Protein 3, Sf9 is a bioengineered protein commonly used in scientific research. Belonging to the Dickkopf (DKK) family, it plays a significant role in the regulation of Wnt signaling pathway, which is crucial for embryonic development and tissue homeostasis. This protein has a molecular weight of approximately X kDa, making it suitable for various biochemical and biophysical studies. Its recombinant form, produced in Spodoptera frugiperda (Sf9) insect cells, offers researchers a reliable and standardized source for investigating the intricate mechanisms of Wnt signaling.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System Sf9 - Baculovirus cells
Purity 90 % by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
37.3 kDa
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation DKK3 protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

ADPAPAPTAT SAPVKPGPAL SYPQEEATLN EMFREVEELM EDTQHKLRSA VEEMEAEEAA AKASSEVNLA NLPPSYHNET NTDTKVGNNT IHVHREIHKI TNNQTGQMVF SETVITSVGD EEGRRSHECI IDEDCGPSMY CQFASFQYTC QPCRGQRMLC TRDSECCGDQ LCVWGHCTKM ATRGSNGTIC DNQRDCQPGL CCAFQRGLLF PVCTPLPVEG ELCHDPASRL LDLITWELEP DGALDRCPCA SGLLCQPHSH SLVYVCKPTF VGSRDQDGEI LLPREVPDEY EVGSFMEEVR QELEDLERSL TEEMALREPA AAAAALLGGE EIHHHHHH.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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DKK3 Sf9

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