DKK3

Alternative Names: Dickkopf 3 homolog (Xenopus laevis), Dkk-3, dickkopf-related protein 3, regulated in glioma, REIC, RIG, RIG-like 5-6, RIG-like 7-1.

Dickkopf-related protein 3 (DKK3), a member of the DKK protein family (DKK-1, 2, 3, and -4), is a secreted glycoprotein consisting of 350 amino acids. It contains an N-terminal signal peptide and two conserved cysteine-rich domains, with a 12 amino acid linker region separating the domains. DKK3 plays a role in embryonic development by inhibiting the WNT signaling pathway. Additionally, DKK3 gene expression is reduced in various cancer cell lines and it may function as a tumor suppressor gene.

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  • Sku: PSB-pro-1175-5µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Dickkopf-Related Protein 3 (Dkk-3) is a member of the Dickkopf family of proteins, which are known for their role in regulating the Wnt signaling pathway. Dkk-3 is a secreted glycoprotein that plays a significant role in modulating cell growth and differentiation. With a molecular weight of approximately 36 kDa, Dkk-3 acts as an antagonist of the Wnt signaling pathway by binding to the LRP5/6 co-receptor, thereby inhibiting the canonical Wnt signaling cascade. Its involvement in various cellular processes makes Recombinant Human Dickkopf-Related Protein 3 a subject of interest in scientific research and drug development.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 85.0% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Monomer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The DKK3 solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 1M Urea, 1mM DTT and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHYHH SSGLVPRGSH MGSMAPAPTA TSAPVKPGPA LSYPQEEATL NEMFREVEEL MEDTQHKLRS AVEEMEAEEA AAKASSEVNL ANLPPSYHNE TNTDTKVGNN TIHVHREIHK ITNNQTGQMV FSETVITSVG DEEGRRSHEC IIDEDCGPSM YCQFASFQYT CQPCRGQRML CTRDSECCGD QLCVWGHCTK MATRGSNGTI CDNQRDCQPG LCCAFQRGLL FPVCTPLPVE GELCHDPASR LLDLITWELE PDGALDRCPC ASGLLCQPHS HSLVYVCKPT FVGSRDQDGE ILLPREVPDE YEVGSFMEEV RQELEDLERS LTEEMALREP AAAAAALLGG EEI

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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DKK3
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