DKK2

Alternative Names: Dickkopf 2 homolog (Xenopus laevis), hDkk-2, dickkopf related protein-2.

Dickkopf-related protein 2 (DKK2) is a crucial member of the dickkopf family, which plays a vital role in vertebrate development. Its primary function is to inhibit Wnt regulated processes, such as antero-posterior axial patterning, limb development, somitogenesis, and eye formation. In adults, DKK2 is involved in various functions related to bone and diseases like cancer and Alzheimer's disease. DKK2 contains two regions rich in cysteine and is known to exert its effects on embryonic development through interactions with the Wnt signaling pathway. Its role as an agonist or antagonist of Wnt/beta-catenin signaling depends on factors like the cellular environment and the presence of the co-factor kremen 2. Furthermore, the activity of DKK2 protein is regulated by binding with the Wnt co-receptor LRP6.

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  • Sku: PSB-pro-1205-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Dickkopf-Related Protein 2 (Dkk-2) is a member of the Dickkopf (Dkk) family, which plays a significant role in the regulation of Wnt signaling pathway. This protein is involved in embryonic development, tissue differentiation, and cell fate determination. With a molecular weight of approximately 35 kDa, Recombinant Human Dkk-2 acts as an antagonist of the Wnt signaling pathway by binding to low-density lipoprotein receptor-related protein 6 (LRP6) co-receptor, thereby inhibiting the interaction between Wnt ligands and the Frizzled receptor. By providing a competitive blockade, Dkk-2 negatively modulates Wnt signaling, influencing various cellular processes.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The DKK2 solution (0.25mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSMKLNSIK SSLGGETPGQ AANRSAGMYQ GLAFGGSKKG KNLGQAYPCS SDKECEVGRY CHSPHQGSSA CMVCRRKKKR CHRDGMCCPS TRCNNGICIP VTESILTPHI PALDGTRHRD RNHGHYSNHD LGWQNLGRPH TKMSHIKGHE GDPCLRSSDC IEGFCCARHF WTKICKPVLH QGEVCTKQRK KGSHGLEIFQ RCDCAKGLSC KVWKDATYSS KARLHVCQKI.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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DKK2
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