DHH

Alternative Names: DHH, Desert hedgehog protein, Desert Hedgehog homolog, MGC35145, HHG-3

DHH is a member of the Hedgehog family involved in regulating morphogenesis. It is a precursor protein that undergoes autocatalytic cleavage, producing a soluble N-terminal portion with signaling activity and a C-terminal portion for precursor processing. The C-terminal product attaches a cholesterol moiety to the N-terminal product, limiting its movement within the organism. Defects in DHH have been linked to conditions like partial gonadal dysgenesis and minifascicular polyneuropathy. DHH is crucial for male gonadal differentiation and perineurial development, serving as a spermatocyte survival factor in the testes.

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  • Sku: PSB-cyt-467-5µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Desert Hedgehog is a protein belonging to the Hedgehog family, known for its role in embryonic development and cell differentiation. This protein plays a crucial role in regulating various cellular processes, including cell growth and tissue repair. With a molecular weight of approximately 45 kDa, Recombinant Human Desert Hedgehog is commonly used in research and therapeutic applications to study its effects on cellular signaling pathways and potential therapeutic interventions for various diseases.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation DHH solution containing 20mM MES pH-5.5, 0.5mM DTT and 20% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MCGPGRGPVG RRRYARKQLV PLLYKQFVPG VPERTLGASG PAEGRVARGS ERFRDLVPNY NPDIIFKDEE NSGADRLMTE RCKERVNALA IAVMNMWPGV RLRVTEGWDE DGHHAQDSLH YEGRALDITT SDRDRNKYGL LARLAVEAGF DWVYYESRNH VHVSVKADNS LAVRAGG.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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DHH
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