DEDD

Alternative Names: CASP8IP1, DEDD1, DEFT, FLDED1, KE05, DEDPro1, Death effector domain-containing testicular molecule.

DEDD is a cytoplasmic protein that plays a role in cell death. Its nuclear localization is associated with its ability to induce cell death. During CD95-mediated apoptosis, DEDD moves into the nucleus and localizes to nucleoli-like structures. It activates caspase-6 and inhibits RNA polymerase I-dependent transcription. DEDD is expressed in various tissues but is most abundant in the testis. Overexpression of DEDD can lead to weak apoptosis.

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  • Sku: PSB-pro-1349-2µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human Death Effector Domain Containing, commonly referred to as RHDED, is a protein belonging to the Death Effector Domain (DED) family. This protein plays a significant role in various cellular processes, particularly in the regulation of programmed cell death, or apoptosis. RHDED is a crucial component in the apoptotic signaling pathway, facilitating the activation of caspase enzymes and subsequent cell death. With a molecular weight of approximately X kDa, RHDED exhibits a high affinity for interacting with other proteins involved in apoptosis regulation, making it an important target for further research and therapeutic development in various diseases.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 85.0% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
38.9 kDa
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation DEDD protein solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MAGLKRRASQ VWPEEHGEQE HGLYSLHRMF DIVGTHLTHR DVRVLSFLFV DVIDDHERGL IRNGRDFLLA LERQGRCDES NFRQVLQLLR IITRHDLLPY VTLKRRRAVC PDLVDKYLEE TSIRYVTPRA LSDPEPRPPQ PSKTVPPHYP VVCCPTSGPQ MCSKRPARGR ATLGSQRKRR KSVTPDPKEK QTCDIRLRVR AEYCQHETAL QGNVFSNKQD PLERQFERFN QANTILKSRD LGSIICDIKF SELTYLDAFW RDYINGSLLE ALKGVFITDS LKQAVGHEAI KLLVNVDEED YELGRQKLLR NLMLQALP.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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DEDD

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