DDR1

Alternative Names: CD167 Antigen-Like Family Member A, CD167a Antigen, Cell Adhesion Kinase, Discoidin Domain Receptor Family, Member 1, Discoidin Domain Receptor Tyrosine Kinase 1, Discoidin Receptor Tyrosine Kinase, EC 2.7.10, EC 2.7.10.1, EDDR1, Epithelial Discoidin Domain Receptor 1, HGK2, MCK-10, MCK10, Mammary Carcinoma Kinase 10, Neuroepithelial Tyrosine Kinase, Neurotrophic Tyrosine Kinase, NEP, NTRK4, PTK3, PTK3A, PTK3A Protein Tyrosine Kinase 3A, Protein-Tyrosine Kinase 3A, Protein-Tyrosine Kinase RTK-6, Receptor, RTK6, TRK E, TRKE, Tyrosine Kinase CAK, Tyrosine Kinase DDR, Tyrosine-Protein Kinase CAK, Tyrosine-Protein Kinase RTK-6.

DDR1, or Discoidin Domain Receptor Tyrosine Kinase 1, is a transmembrane glycoprotein belonging to the discoidin-like domain containing subfamily of receptor tyrosine kinases. It acts as a cell surface receptor for fibrillar collagen and plays a role in various cellular processes such as cell attachment to the extracellular matrix, extracellular matrix remodeling, cell migration, differentiation, survival, and cell proliferation. DDR1 is primarily expressed in epithelial cells, with higher levels observed in the kidney, lung, gastrointestinal tract, and brain. It is also found to be significantly upregulated in multiple human tumors.

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  • Sku: PSB-pka-103-1µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Discoidin Domain Receptor Tyrosine Kinase 1 (DDR1) is a protein belonging to the receptor tyrosine kinase family. It plays a significant role in cell adhesion, migration, and extracellular matrix remodeling. DDR1 is involved in various cellular processes, including tissue development, wound healing, and cancer progression. With a molecular weight of approximately 125 kDa, this protein is crucial for mediating cell signaling pathways and regulating cellular responses. Understanding the functions and mechanisms of DDR1 can provide valuable insights into its potential as a therapeutic target for various diseases.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System Sf9 - Baculovirus cells
Purity 90.0 % by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 71.0 kDa
Structure Contact for Details
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation DDR1 protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

DMKGHFDPAK CRYALGMQDR TIPDSDISAS SSWSDSTAAR HSRLESSDGD GAWCPAGSVF PKEEEYLQVD LQRLHLVALV GTQGRHAGGL GKEFSRSYRL RYSRDGRRWM GWKDRWGQEV ISGNEDPEGV VLKDLGPPMV ARLVRFYPRA DRVMSVCLRV ELYGCLWRDG LLSYTAPVGQ TMYLSEAVYL NDSTYDGHTV GGLQYGGLGQ LADGVVGLDD FRKSQELRYV WPGYDYVGWS NHSFSSGYVE MEFEFDRLRA FQAMQVHCNN MHTLGARLPG GVECRFRRGP AMAWEGEPMR HNLGGNLGDP RARAVSVPLG GRVARFLQCR FLFAGPWLLF SEISFISDVV NNSSPALGGT FPPAPWWPPG PPPTNFSSLE LEPRGQQPVA KAEGSPTALE PKSCDKTHTC PPCPAPELLG GPSVFLFPPK PKDTLMISRT PEVTCVVVDV SHEDPEVKFN WYVDGVEVHN AKTKPREEQY NSTYRVVSVL TVLHQDWLNG KEYKCKVSNK ALPAPIEKTI SKAKGQPREP QVYTLPPSRD ELTKNQVSLT CLVKGFYPSD IAVEWESNGQ PENNYKTTPP VLDSDGSFFL YSKLTVDKSR WQQGNVFSCS VMHEALHNHY TQKSLSLSPG KHHHHHH.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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DDR1
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