DCUN1D1

Alternative Names: DCN1, defective in cullin neddylation 1-domain containing 1 (S. cerevisiae), DCUN1L1, DCUN1 domain-containing protein 1, DCN1-like protein 1, Defective in cullin neddylation protein 1-like protein 1, RP42, RP42 homolog, SCCRO, Squamous cell carcinoma-related oncogene, SCRO, Tes3.

DCUN1D1 is involved in the cancerous transformation of squamous cell lineage. This protein regulates Gli1, a key regulator of the hedgehog pathway, which plays a fundamental role in the development, maintenance, and regeneration of adult tissues.

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  • Sku: PSB-pro-078-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Title

Product Details

Product Description

Recombinant Human DCN1 Defective in Cullin Neddylation 1 Domain Containing 1 is a protein belonging to the DCN1 family, which plays a critical role in the regulation of protein neddylation, a post-translational modification process. With a molecular weight of approximately X kDa, this protein is involved in the assembly and activation of cullin-RING E3 ubiquitin ligases (CRLs), which are essential for the degradation of target proteins. By mediating the transfer of the ubiquitin-like protein Nedd8 to cullins, Recombinant Human DCN1 Defective in Cullin Neddylation 1 Domain Containing 1 contributes to the proper functioning of CRLs, thereby influencing various cellular processes.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
32.2 kDa
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation The DCUN1D1 protein solution (1mg/1ml) is formulated in 20mM Tris-HCl buffer (pH8.0) 0.1M NaCl and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MNKLKSSQKD KVRQFMIFTQ SSEKTAVSCL SQNDWKLDVA TDNFFQNPEL YIRESVKGSL DRKKLEQLYN RYKDPQDENK IGIDGIQQFC DDLALDPASI SVLIIAWKFR AATQCEFSKQ EFMDGMTELG CDSIEKLKAQ IPKMEQELKE PGRFKDFYQF TFNFAKNPGQ KGLDLEMAIA YWNLVLNGRF KFLDLWNKFL LEHHKRSIPK DTWNLLLDFS TMIADDMSNY DEEGAWPVLI DDFVEFARPQ IAGTKSTTV

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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DCUN1D1

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