DCTN2 (1-406)

Alternative Names: DCTN2, DCTN50, DYNAMITIN, Dynactin 2 (P50), Dynactin Complex 50 KDa Subunit, Dynactin Complex 50 KD Subunit, Dynactin Subunit 2, Epididymis Secretory Protein Li 77, HEL-S-77, P50 Dynamitin, RBP50, 50 KDa Dynein-Associated Polypeptide, 50 KD Dynein-Associated Polypeptide, DCTN-50.

DCTN2 is a subunit of the dynactin complex, which consists of multiple subunits of varying sizes. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in several cellular functions such as ER-to-Golgi transport, movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. DCTN2 is present in multiple copies per dynactin molecule and is composed of three alpha-helical coiled-coil domains that facilitate association with other dynactin subunits. DCTN2 directly interacts with the largest subunit (p150) of dynactin, which helps secure p150 in place. DCTN2 influences the binding of cytoplasmic dynein to an organelle and contributes to the alignment of chromosomes and organization of the spindle during mitosis. It also plays a role in anchoring microtubules to centrosomes and in synapse formation during brain development.

  •
  • Sku: PSB-pro-1820-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
Shipping calculated at checkout.

Contact us directly for international purchases.

Title
Report Product Listing Issue (e.g. Missing Data, or Questions)
Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Dynactin 2 (1-406 a.a.) is a protein that belongs to the dynactin family. With a weight of approximately X kDa, it plays a significant role in cellular processes such as intracellular transport and organelle positioning. This recombinant protein is produced through genetic engineering techniques, ensuring its purity and consistency. Its precise structure and function make it an ideal tool for scientific research and drug development in various fields, including cell biology and neurology.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 47.2 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation DCTN2 protein solution (0.5mg/ml) containing 20mM Tris-HCl (pH8.0), 20% glycerol, 0.15M NaCl and 1mM DTT.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSMADPKYA DLPGIARNEP DVYETSDLPE DDQAEFDAFA QELEELTSTS VEHIIVNPNA AYDKFKDKRV GTKGLDFSDR IGKTKRTGYE SGEYEMLGEG LGVKETPQQK YQRLLHEVQE LTTEVEKIKT TVKESATEEK LTPVLLAKQL AALKQQLVAS HLEKLLGPDA AINLTDPDGA LAKRLLLQLE ATKNSKGGSG GKTTGTPPDS SLVTYELHSR PEQDKFSQAA KVAELEKRLT ELETAVRCDQ DAQNPLSAGL QGACLMETVE LLQAKVSALD LAVLDQVEAR LQSVLGKVNE IAKHKASVED ADTQSKVHQL YETIQRWSPI ASTLPELVQR LVTIKQLHEQ AMQFGQLLTH LDTTQQMIAN SLKDNTTLLT QVQTTMRENL ATVEGNFASI DERMKKLGK.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
View full details

DCTN2 (1-406)
SUBHEADING

Recently viewed products