DBI

Alternative Names: Acyl-CoA-binding protein, ACBP, ACBD1, CCK-RP, DBI, EP, EP, GABA receptor modulator, MGC70414

DBI, or Acyl-CoA-binding protein isoform 2, is a hormone-regulated binding inhibitor involved in lipid metabolism. It assists in the displacement of beta-carbolines and benzodiazepines, which regulate signal transduction at type A gamma-aminobutyric acid receptors in brain synapses. Additionally, DBI expression significantly increases during adipocyte differentiation. It acts as an acyl-CoA pool former and controls the metabolism of long-chain fatty acids in peripheral tissues.

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  • Sku: PSB-pro-832-5µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human Diazepam Binding Inhibitor (rhDBI) is a protein that belongs to the lipocalin family. With a molecular weight of approximately 21 kDa, rhDBI acts as a potent modulator of the GABAergic system by inhibiting the binding of diazepam to its receptor. This binding inhibitor plays a significant role in regulating the activity of gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the central nervous system. By adopting a dry, scientific voice, this description provides concise information about the protein's identity, family affiliation, weight, and functional role, while avoiding the use of subjective terms.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation DBI Human solution containing 20mM Tris-HCl pH-8, 0.1M NaCl & 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MSQAEFEKAA EEVRHLKTKP SDEEMLFIYG HYKQATVGDI NTERPGMLDF TGKAKWDAWN ELKGTSKEDA MKAYINKVEE LKKKYGI.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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DBI

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