DAG1

Alternative Names: Dystroglycan, Dystrophin-associated glycoprotein 1, DAG1, DAG, A3a, AGRNR, 156DAG, MDDGC7, MDDGC9.

Dystroglycan 1 (DAG1) is a component of the dystrophin-glycoprotein complex that connects the subsarcolemmal cytoskeleton to the extracellular matrix through its binding to laminin. The N-terminal domain of alpha-dystroglycan is found in the cerebrospinal fluid. The impact of DAG1 on the nervous system is not well understood. The dystroglycan complex is present in various tissues and plays a role in processes such as assembling laminin and basement membranes, maintaining sarcolemmal stability, promoting cell survival, facilitating peripheral nerve myelination, shaping nodal structure, promoting cell migration, and facilitating epithelial polarization. DAG1 is a possible candidate gene for mutations in autosomal recessive muscular dystrophies. In Duchenne muscular dystrophy, there is a significant reduction of DAG1 levels, which weakens the connection between the sarcolemma and extracellular matrix, making muscle fibers more susceptible to necrosis.

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  • Sku: PSB-pro-1571-2µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Dystroglycan 1 is a protein that plays a significant role in maintaining the structural integrity of muscle tissues. Belonging to the dystroglycan family, this protein acts as a crucial link between the extracellular matrix and the cytoskeleton, enabling proper muscle function. With a weight of approximately X kDa, Recombinant Human Dystroglycan 1 serves as an essential component in various physiological processes, including cell adhesion and signaling pathways. Its precise functions and interactions make it a subject of interest in scientific research aiming to understand and potentially treat muscular dystrophies and related disorders.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 31.87 kDa
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation DAG1 filtered (0.4 µm) and lyophilized from 0.5mg/ml in 0.05M phosphate buffer and 0.075M NaCl, pH 7.4.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MKHHHHHHASHWPSEPSEAV RDWENQLEAS MHSVLSDLHE AVPTVVGIPD GTAVVGRSFR VTIPTDLIAS SGDIIKVSAA GKEALPSWLH WDSQSHTLEG LPLDTDKGVH YISVSATRLG ANGSHIPQTS SVFSIEVYPE DHSELQSVRT ASPDPGEVVS SACAADEPVT VLTVILDADL TKMTPKQRID LLHRMRSFSE VELHNMKLVP VVNNRLFDMS AFMAGPGNAK KVVENGALLS WKLGCSLNQN SVPDIHGVEA PAREGAMSAQ LGYPVVGWHI ANKKPPLPKR VRR.

Storage Instruction

Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.

Sample Prep Instruction

It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. DAG1 is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.

References

Not Available
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DAG1
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