CYP2D6

Alternative Names: Cytochrome P450 2D6, CYPIID6, P450-DB1, Debrisoquine 4-hydroxylase, CYP2D6, CPD6, CYP2D, CYP2D@, CYP2DL1, P450C2D, MGC120389, MGC120390, LKM1, liver/kidney microsomal antigen 1.

Cytochrome P450 2D6 is a microsomal enzyme involved in detoxification reactions of xenobiotic compounds. This enzyme is targeted by autoantibodies against "liver kidney microsomal antigen 1" (LKM 1) in patients with Autoimmune Hepatitis Type 2. These antibodies are also found in patients with hepatitis C viral infection. The International Autoimmune Hepatitis Group has classified AIH type 2 into two subcategories based on the presence of hepatitis C: 2a with HCV and 2b without HCV. Patients with AIH 2a are typically older than 40 and male. Using a purified recombinant Cytochrome P450 2D6 antigen can differentiate autoimmune hepatitis from drug-induced hepatitis, where transient autoantibodies to other P450 family members are present. Immunofluorescence microscopy may not be able to differentiate these antibodies.

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  • Sku: PSB-enz-316-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Title

Product Details

Product Description

Recombinant Human Cytochrome P450 2D6 is an enzyme that belongs to the cytochrome P450 family, specifically the subfamily 2D. This enzyme plays a significant role in the metabolism of a wide range of drugs and xenobiotics. With a molecular weight of approximately 52 kDa, Recombinant Human Cytochrome P450 2D6 is commonly used in drug metabolism studies and pharmaceutical research to better understand drug interactions and variability in drug response among individuals.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System Sf9 - Insect cells
Purity 95 % by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation LKM-1 is supplied in17mM HEPES pH-7.5, 425mM NaCl, 1mM DTT, 1% Triton X-100 and 15% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

Check Uniprot Link

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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CYP2D6

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