CXCL17

Alternative Names: Dendritic cell and monocyte chemokine-like protein, DMC, CXCL17, VEGF coregulated chemokine 1, C-X-C motif chemokine 17, VCC1, Dcip1, VCC-1, UNQ473.

CXCL17 is a secreted molecule similar in size and folding pattern to chemokines CXCL8/IL8 and CXCL14/BRAK. It is produced by airway and intestinal epithelium and triggers chemotaxis of quiescent peripheral blood monocytes and dendritic cells. CXCL17 is also found to be upregulated in endothelial cells forming tubes in vitro. It is thought to play a role in tumor angiogenesis, as it shows correlated expression with VEGF in lung, breast, and esophageal tumors. Rat CXCL17 shares amino acid sequence identity of 82% with mouse and 71% with human CXCL17.

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  • Sku: PSB-chm-019-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human VEGF Co-regulated Chemokine 1 is a member of the chemokine family, specifically known for its role in angiogenesis and inflammation. With a molecular weight of approximately 8.3 kDa, this protein plays a significant role in regulating the migration and activation of immune cells. Recombinant Human VEGF Co-regulated Chemokine 1 is commonly used in research settings to study the mechanisms of angiogenesis and inflammation.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 97.0% by SDS-PAGE
Activity
 The ED50 as determined by its ability to induce VEGF expression using murine endothelial cells is less than 5.0µg/ml, corresponding to a specific activity of > 200IU/mg.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 11.5 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation CXCL17 protein was lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4, containing 3% Trehalose.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

SSLNPGVARG HRDRGQASRR WLQEGGQECE CKDWFLRAPR RKFMTVSGLP KKQCPCDHFK GNVKKTRHQR HHRKPNKHSR ACQQFLKQCQ LRSFALPL.

Storage Instruction

Lyophilized CXCL17 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL17 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized CXCL17 in sterile 18M-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available
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CXCL17
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