CXCL16

Alternative Names: C-X-C Motif Chemokine 16, Chemokine (C-X-C Motif) Ligand 16, CXC Chemokine Ligand 16, CXCL16, CXCLG16, Scavenger Receptor For Phosphatidylserine And Oxidized Low Density Lipoprotein, SR-PSOX, SRPSOX, Transmembrane Chemokine CXCL16, Small-Inducible Cytokine B16, SCYB16.

CXCL16 is a membrane protein with a CXC chemokine domain that is shared by both human and mouse, with a 70% similarity in the chemokine domain and an overall 49% sequence identity. When released from the cell surface, it becomes a 35kDa soluble protein. Its receptor is CXCR6 and it functions as a scavenger receptor on macrophages, binding specifically to OxLDL. This suggests a potential role for CXCL16 in atherogenesis. It also induces chemotactic response and calcium mobilization by binding to CXCR6/Bonzo.

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  • Sku: PSB-chm-029-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human CXCL16 is a chemokine protein that belongs to the CXC subfamily. It plays a role in immune response and inflammation by attracting immune cells to sites of infection or injury. With a molecular weight of approximately 10 kDa, Recombinant Human CXCL16 is commonly used in research settings to study its effects on immune cell migration and activation. Its ability to modulate immune responses makes it a valuable tool for investigating the mechanisms underlying inflammatory diseases and potential therapeutic interventions.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 97.0% by SDS-PAGE
Activity
 The ED50, as measured by its ability to chemoattract mouse CXCR6-transfected mouse BaF3 cells, is less than 12ng/ml.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation CXCL16 protein was lyophilized from a 0.2µm filtered solution in PBS.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

NEGSVTGSCY CGKRISSDSP PSVQFMNRLR KHLRAYHRCL YYTRFQLLSW SVCGGNKDPW VQELMSCLDL KECGHAYSGI VAHQKHLLP.

Storage Instruction

Lyophilized CXCL16 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL16 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized CXCL16 in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available
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CXCL16
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