CXADR

Alternative Names: Coxsackie Virus And Adenovirus Receptor, CAR, Coxsackievirus B-Adenovirus Receptor, HCVADR, 46 KD Coxsackievirus And Adenovirus Receptor (CAR) Protein 11, CVB3-Binding Protein, CAR4/6, HCAR.

CXADR is a crucial component of the epithelial apical junction complex that plays a significant role in maintaining the integrity of tight junctions. It acts as a homophilic cell adhesion molecule and facilitates the relocation of leukocytes across the epithelial barrier through adhesive interactions with AMICA1/JAML, a transmembrane protein on the leukocyte plasma membrane. Multiple transcript variants encoding distinct isoforms of this gene have been identified. Pseudogenes of CXADR have been found on chromosomes 15, 18, and 21.

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  • Sku: PSB-pro-1548-5µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human Coxsackie Virus And Adenovirus Receptor (CAR) is a transmembrane glycoprotein that plays a significant role in viral infection and cell adhesion. Belonging to the immunoglobulin superfamily, CAR acts as a receptor for both Coxsackie viruses and adenoviruses, facilitating their entry into host cells. With a molecular weight of approximately 46 kDa, CAR is involved in the initial steps of viral infection, mediating attachment and internalization. Its precise binding and signaling mechanisms make CAR a subject of extensive research in understanding viral pathogenesis and developing targeted therapeutic interventions.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
26.0 kDa
Structure Homophilic
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation The CXADR solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 1mM DTT and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSLSITTPE EMIEKAKGET AYLPCKFTLS PEDQGPLDIE WLISPADNQK VDQVIILYSG DKIYDDYYPD LKGRVHFTSN DLKSGDASIN VTNLQLSDIG TYQCKVKKAP GVANKKIHLV VLVKPSGARC YVDGSEEIGS DFKIKCEPKE GSLPLQYEWQ KLSDSQKMPT SWLAEMTSSV ISVKNASSEY SGTYSCTVRN RVGSDQCLLR LNVVPPSNKA G.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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CXADR

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