CUL1

Alternative Names: Complement C2, C2, C3/C5 convertase.

C2 functions as the proteolytic component of the C3 and C5 convertases in both pathways. The initiation of each pathway leads to the creation of enzyme complexes that attach to the surface being targeted. These complexes contain C1s and MASP, which activate both C4 and C2. They break a peptide bond in C4, resulting in the deposition of C4b on the surface, and also fragment C2 into two smaller pieces.

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  • Sku: PSB-pro-268-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Title

Product Details

Product Description

Recombinant Human Cullin-1 is a protein that belongs to the Cullin family, which plays a crucial role in the regulation of protein degradation and cell cycle progression. With a molecular weight of approximately 80 kDa, this protein serves as a scaffold for the assembly of the SCF (Skp1-Cullin-1-F-box protein) ubiquitin ligase complex. Through its involvement in the ubiquitin-proteasome system, Recombinant Human Cullin-1 contributes to the targeted degradation of specific proteins, thereby influencing various cellular processes.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System Human Plasma
Purity 95.0 by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) No
Molecular Weight
N/A
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation 25mM sodium phosphate and 100mM NaCl, pH 6.0.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

Check Uniprot Link

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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CUL1

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