ctxB

Alternative Names: Cholera enterotoxin subunit B, Cholera enterotoxin B chain, Cholera enterotoxin gamma chain, Choleragenoid, ctxB, toxB

Cholera Toxin B (ctxB) is a protein complex produced by Vibrio cholerae bacteria that causes severe diarrhea in cholera patients. The toxin is made up of six protein subunits: one A subunit and five B subunits, known as AB5. Subunit B attaches to cells, while subunit A activates a G protein that then activates adenylate cyclase. The B subunits form a circular structure, while the A subunit has two important segments: CTA1, which is an enzyme that modifies G proteins, and CTA2, which forms a long alpha helix that fits within the B subunit ring's central pore.

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  • Sku: PSB-pro-2605-50ug
  • Vendor: ProSpec-Tany
$90.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

The Recombinant Cholera Toxin B subunit is a protein derived from the bacterium Vibrio cholerae, responsible for causing the infectious disease cholera. Belonging to the family of cholera toxins, this subunit plays a significant role in the pathogenesis of cholera by facilitating the binding of the toxin to host cells. With a molecular weight of approximately X kDa, this protein is a critical component in the development of vaccines and diagnostic tools for cholera. Its structural and functional characteristics make it a valuable target for research and potential therapeutic interventions.

Current Lead Time

7-14 Days

Product Specifications

Species
 Bacteria
Expression System E. coli
Purity 98.0 % by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 11.6 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation ctxB is supplied as a 0.2 μm filtered solution conteining 5mM PB, pH 7.0, 75mM NaCl, and 50 % glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

TPQNITDLCA EYHNTQIYTL NDKIFSYTES LAGKREMAII TFKNGAIFQV EVPGSQHIDS QKKAIERMKD TLRIAYLTEA KVEKLCVWNN KTPHAIAAIS MAN.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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ctxB
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