CTLA4, igG-His

Alternative Names: CD, CD152, CTLA4, CTLA-4, Cytotoxic T-Lymphocyte Associated Antigen-4, ALPS5, CELIAC3, GRD4, GSE, IDDM12, igG-His Tag.

CTLA-4 is an immunoglobulin superfamily member that produces a protein responsible for transmitting inhibitory signals to T cells. The protein consists of a V domain, transmembrane domain, and cytoplasmic tail. Different isoforms of this protein have been identified through alternative transcriptional splice variants. The membrane-bound isoform acts as a dimer linked by a disulfide bond, while the soluble isoform is a monomer. Mutations in the CTLA-4 gene have been linked to various autoimmune diseases such as insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, and thyroid-associated orbitopathy.

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  • Sku: PSB-cyt-985-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
 per 
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Title

Product Details

Product Description

Recombinant Human Cytotoxic T-Lymphocyte Associated Antigen-4, igG-His Tag is a protein belonging to the immunoglobulin superfamily. It plays a key role in regulating T-cell activation and immune responses. This protein has a molecular weight of approximately 60 kDa and is commonly used in research and therapeutic applications for its ability to modulate immune responses.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System Sf9 - Baculovirus cells
Purity 95% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
40.8 kDa
Structure Dimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation CTLA4 protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

ADLKAMHVAQ PAVVLASSRG IASFVCEYAS PGKATEVRVT VLRQADSQVT EVCAATYMMG NELTFLDDSI CTGTSSGNQV NLTIQGLRAM DTGLYICKVE LMYPPPYYLG IGNGTQIYVI DPEPCPDSDL EPKSCDKTHT CPPCPAPELL GGPSVFLFPP KPKDTLMISR TPEVTCVVVD VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ YNSTYRVVSV LTVLHQDWLN GKEYKCKVSN KALPAPIEKT ISKAKGQPRE PQVYTLPPSR DELTKNQVSL TCLVKGFYPS DIAVEWESNG QPENNYKTTP PVLDSDGSFF LYSKLTVDKS RWQQGNVFSC SVMHEALHNH YTQKSLSLSP GKHHHHHH.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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CTLA4, igG-His

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