CTHRC1

Alternative Names: CTHRC1, Collagen Triple Helix Repeat Containing 1, Protein NMTC1

Collagen triple helix repeat-containing protein 1 (CTHRC1) is a 28kDa glycosylated protein that regulates collagen matrix deposition. It is highly conserved from lower chordates to mammals and is mainly associated with calcified tissues and cartilaginous matrix. CTHRC1 is not found in endothelial cells. It can be detected in the plasma of healthy individuals and its levels increase during pregnancy, in diabetes, inflammatory and infectious conditions, and acute myeloid leukemia. However, CTHRC1 is not present in subjects with solid cancers. CTHRC1 also plays a role in hormonal functions, such as regulating lipid storage and cellular glycogen levels, which has potential implications for cell metabolism and physiology. Deletion or inactivation of the CTHRC1 gene in mice results in fatty liver formation and low bone mass.

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  • Sku: PSB-pro-2027-5µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Collagen Triple Helix Repeat Containing 1 (RHOT1) is a protein that belongs to the collagen family, which is characterized by its triple helical structure. RHOT1 plays a significant role in various cellular processes, including mitochondrial dynamics and apoptosis. With a weight of approximately X kilodaltons, RHOT1 is involved in maintaining the structural integrity of the mitochondrial network, facilitating the fusion and fission events necessary for proper cellular function. Understanding the functional mechanisms of RHOT1 can provide valuable insights into mitochondrial-related diseases and potential therapeutic targets.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Monomer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation CTHRC1 protein solution (1mg/ml) containing 20mM Tris-HCl (pH 8.0) and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MSEIPKGKQK AQLRQREVVD LYNGMCLQGP AGVPGRDGSP GANGIPGTPG IPGRDGFKGE KGECLRESFE ESWTPNYKQC SWSSLNYGID LGKIAECTFT KMRSNSALRV LFSGSLRLKC RNACCQRWYF TFNGAECSGP LPIEAIIYLD QGSPEMNSTI NIHRTSSVEG LCEGIGAGLV DVAIWVGTCS DYPKGDASTG WNSVSRIIIE ELPK.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
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References

Not Available
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CTHRC1
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