CTGF, His

Alternative Names: CCN2, NOV2, HCS24, IGFBP8, MGC102839, CTGF, Connective Tissue Growth Factor

Connective Tissue Growth Factor, a member of the CCN family of proteins, plays a crucial role in various cellular functions. The CCN family includes six members in humans: Cyr61, CTGF, Nov, and WISP-1, 2, and 3. These proteins are associated with the Extracellular Matrix and the cell membrane. CCN proteins regulate proliferation, differentiation, survival, adhesion, and migration in cells derived from the three embryonic sheets. They are involved in the development of various organs and tissues during embryonic development and play a role in wound healing and pathologies such as fibrosis and tumorigenesis in adulthood. The full-length CCN proteins exhibit antiproliferative activity, while truncated isoforms may stimulate proliferation and behave as oncogenes. The full-length protein consists of four modules: Module I with resemblance to Insulin-like Growth Factor Binding Proteins, Module II with similarity to Von Willebrand Factor Type C repeat, Module III with sequences related to Thrombospondin type 1 repeat, and Module IV designated as CT. Proteolysis of full-length CCN proteins can produce peptides with high affinity for ligands, resulting in biological activity. Elevated CCN2 expression has been detected in various cancers, indicating its potential role in tumorigenesis and angiogenesis. Studies have shown a correlation between CCN2 expression and tumor malignancy, implicating CCN2 in cell proliferation and tumor progression. Further research is

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  • Sku: PSB-cyt-438-5µg
  • Vendor: ProSpec-Tany
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Product Details

Product Description

Recombinant Human Connective Tissue Growth Factor, His Tag is a protein belonging to the growth factor family. It plays a role in cell proliferation, differentiation, and adhesion in various tissues. With a molecular weight of approximately 13.9 kDa, this protein is commonly used in research and biotechnological applications for its ability to stimulate cellular processes related to tissue repair and regeneration.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 85.0% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation CTGF protein (1mg/ml) is supplied in 20mM Tris-HCl, pH-8 and 10% Glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MQNCSGPCRC PDEPAPRCPA GVSLVLDGCG CCRVCAKQLG ELCTERDPCD PHKGLFCDFG SPANRKIGVC TAKDGAPCIF GGTVYRSGES FQSSCKYQCT CLDGAVGCMP LCSMDVRLPS PDCPFPRRVK LPGKCCEEWV CDEPKDQTVV GPALAAYRLE DTFGPDPTMI RANCLVQTTE WSACSKTCGM GISTRVTNDN ASCRLEKQSR LCMVRPCEAD LEENIKKGKK CIRTPKISKP IKFELSGCTS MKTYRAKFCG VCTDGRCCTP HRTTTLPVEF KCPDGEVMKK NMMFIKTCAC HYNCPGDNDI FESLYYRKMY GDMA.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
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References

Not Available
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CTGF, His
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