• Home
  • CTGF (183-255)

CTGF (183-255)

Alternative Names: Connective Tissue Growth Factor, CCN2, NOV2, HCS24, IGFBP8, MGC102839, CTGF.

Connective Tissue Growth Factor (CTGF) belongs to the CCN family of proteins, which consists of six members in humans: Cyr61, CTGF, Nov, WISP-1, WISP-2, and WISP-3. CCN proteins play a role in regulating cellular functions such as proliferation, differentiation, adhesion, and migration. They are expressed in various embryonic tissues and are involved in the development of organs like the kidney, nervous system, and bone. In adulthood, they are important for wound healing, bone repair, and can be implicated in diseases like cancer and fibrosis. Full-length CCN proteins have antiproliferative effects, while truncated isoforms may stimulate proliferation. The full-length CTGF protein consists of four modules with unique functions, including sequences that aid in cell adhesion and binding to glycoconjugates. Proteolysis of full-length CCN proteins can produce bioactive peptides, with some isoforms having oncogenic potential. Elevated CCN2 expression has been linked to various cancers, including breast and pancreatic tumors. Studies have also shown a correlation between CCN2 expression and tumor malignancy. In brain tumors, CCN2 has been associated with angiogenesis and cell proliferation. In leukemia, CCN2 expression was found in a higher proportion of mononuclear cells.

  •
  • Sku: PSB-cyt-1174-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
Shipping calculated at checkout.

Contact us directly for international purchases.

Title
Report Product Listing Issue (e.g. Missing Data, or Questions)
Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Connective Tissue Growth Factor (183-255 a.a.) is a member of the CCN family of proteins, which are involved in various cellular processes such as cell proliferation, adhesion, migration, and differentiation. This specific isoform of Connective Tissue Growth Factor has a molecular weight of approximately 8.6 kDa and plays a role in promoting the synthesis of extracellular matrix proteins, including collagen and fibronectin. Its ability to regulate cell behavior and tissue repair makes it a valuable tool in research and therapeutic applications for various medical conditions.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System HEK 293
Purity 95.0 % by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) No
Molecular Weight
 N/A
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation CTGF filtered (0.4 µm) and lyophilized from 0.5mg/ml in 20 mM Tris buffer and 50 mM NaCl, pH 7.5.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MHHHHHHRLE DTFGPDPTMI RANCLVQTTE WSACSKTCGM GISTRVTNDN ASCRLEKQSR LCMVRPCEAD LEENIKKGKK.

Storage Instruction

Store lyophilized protein at -20° C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4° C for a limited period of time; it does not show any change after two weeks at 4° C.

Sample Prep Instruction

It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely.

References

Not Available
View full details

CTGF (183-255)
SUBHEADING

Recently viewed products