CTGF (182-250)

Alternative Names: CCN2, CTGF, Connective Tissue Growth Factor, HCS24, IGFBP8, MGC102839, NOV2

Connective Tissue Growth Factor (CTGF) is a member of the CCN family of proteins, which includes six members in humans: Cyr61, CTGF, Nov, and WISP-1, 2, and 3. These proteins are associated with the Extracellular Matrix (ECM) and play a role in various cellular functions such as proliferation, differentiation, and adhesion. During development, they are involved in the formation of different tissues and organs. In adulthood, they are implicated in processes like wound healing and bone fracture repair. Full-length CCN proteins have antiproliferative activity, while truncated isoforms may stimulate proliferation. The protein consists of four distinct modules, each with specific functions. Proteolysis of CCN proteins can lead to the production of bioactive peptides, impacting cellular responses. Elevated levels of CCN2 have been observed in various tumors, suggesting a role in tumorigenesis and angiogenesis. Studies have shown a correlation between CCN2 expression and tumor malignancy in different types of cancer. Additionally, CCN2 has been linked to cell proliferation and cell cycle progression, indicating its significance in cancer development and progression.

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  • Sku: PSB-cyt-526-4µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human Connective Tissue Growth Factor (182-250 a.a.) is a member of the CCN family of proteins, known for their roles in cell adhesion, migration, proliferation, and differentiation. This specific isoform consists of amino acids 182 to 250 and plays a crucial role in promoting the synthesis of extracellular matrix proteins and regulating tissue repair processes. With a molecular weight of approximately 18-25 kDa, Recombinant Human Connective Tissue Growth Factor (182-250 a.a.) is commonly used in research studies investigating fibrosis, wound healing, and tissue regeneration.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Lyophilized
Formulation Lyophilized without any additives.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

Check Uniprot Link

Storage Instruction

Lyophilized CTGF although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CTGF should be stored at 4°C between 2-7 days and for future use below -18°C.For long-term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized CTGF in sterile 18MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available

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CTGF (182-250)

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