CTGF

Alternative Names: CCN2, NOV2, HCS24, IGFBP8, MGC102839, CTGF, Connective Tissue Growth Factor

Connective Tissue Growth Factor (CTGF) is a member of the CCN family of proteins, which includes six members in humans: Cyr61, CTGF, Nov, WISP-1, WISP-2, and WISP-3. These proteins are associated with the Extracellular Matrix (ECM) and cell membrane. CCN proteins play a role in regulating cellular functions such as proliferation, differentiation, survival, adhesion, and migration. They are expressed during embryonic development and play a role in various tissues including kidney, nervous system, muscle, bone marrow, cartilage, and bone.<br />Full-length CCN proteins exhibit antiproliferative activity, while truncated isoforms are likely to stimulate proliferation and act as oncogenes. The full-length CTGF protein consists of four modules, each with specific functions. Proteolysis of full-length CTGF proteins, such as CCN2 and CCN3, may result in the production of CCN-derived peptides with high affinity for ligands. Elevated expression of CCN2 has been detected in various pathological conditions, such as invasive mammary ductal carcinomas and pancreatic tumors. In brain tumors, CCN2 plays a role in angiogenesis and is associated with increased cell proliferation. Downregulation of CCN2 expression leads to growth arrest, while overexpression induces cell proliferation.<br />CCN2 expression has also been observed in mononuclear cells of patients with acute lymphoblastic leukemia.

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  • Sku: PSB-cyt-541-5µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Connective Tissue Growth Factor is a protein that belongs to the CCN family of growth factors. It plays a role in promoting cell proliferation, differentiation, and extracellular matrix production in various tissues. This protein has a molecular weight of approximately 36 kDa and is commonly used in research and therapeutic applications for its ability to stimulate tissue repair and regeneration.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 90 by SDS-PAGE
Activity
 Determined by the dose-dependent stimulation of the proliferation of HUVEC cells. The expected ED50 for this effect is 1-2µg/ml, corresponding to a specific activity of 500-1000units/mg. Determined by the dose-dependent stimulation of the proliferation of HUVEC cells. The expected ED50 for this effect is 1-2µg/ml, corresponding to a specific activity of 500-1000units/mg.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation CTGF was Lyophilized from a sterile filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA).

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGKKCIRTPK ISKPIKFELS GCTSMKTYRA KFCGVCTDGR CCTPHRTTTL PVEFKCPDGE VMKKNMMFIK TCACHYNCPG DNDIFESLYY RKMYGDMA.

Storage Instruction

Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized CTGF in sterile 18MΩcm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. ;

References

Not Available
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CTGF
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