CTF1, His

Alternative Names: Cardiophin 1, CTF1, CT1, CT-1

Cardiotrophin 1 (CT-1) is a member of the interleukin-6 superfamily that consists of 201 amino acids. It induces hypertrophic response in cardiac myocytes by activating the gp130 dependent signaling pathway, leading to stimulation of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway. CT-1 mRNA levels have been found in both cardiac myocytes and nonmyocytes, as well as in normal adult human lung and fetal and adult airway smooth muscle cells.<br />Additionally, CT-1 has neurotrophic functions, with CT-1 deficiency causing increased motoneuron cell death in mice during certain developmental periods. It also acts as a hepatocyte survival factor, protecting against hepatocellular damage in animal models of acute liver injury. Following hypoxic stimulation, CT-1 expression increases and offers protection to cardiac cells during simulated ischaemia/reoxygenation. Furthermore, CT-1 can induce the expression of heat shock proteins (hsps) in cardiac cells.<br />Moreover, Cardiotrophin-1 has been shown to increase the expression levels of various markers in the heart including ANP, BNP, and angiotensinogen mRNA. Levels of CT-1 have been significantly elevated in patients with heart failure, dilatative cardiomyopathy, mitral regurgitation, stable/unstable angina, and following acute myocardial infarction.

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  • Sku: PSB-cyt-436-2µg
  • Vendor: ProSpec-Tany
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Product Details

Product Description

Recombinant Human Cardiotrophin-1, His Tag is a protein belonging to the interleukin-6 family. This protein plays a role in promoting cardiac myocyte survival and growth. With a molecular weight of approximately 22 kDa, Recombinant Human Cardiotrophin-1, His Tag is commonly used in research studies to investigate its potential therapeutic applications in cardiovascular diseases.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation CTF1 was filtered (0.4µm) and lyophilized from 0.5 mg/ml in 0.05M Acetate buffer pH-4.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MRGSHHHHHH GSSRREGSLE DPQTDSSVSL LPHLEAKIRQ THSLAHLLTK YAEQLLQEYV QLQGDPFGLPSFSPPRLPVA GLSAPAPSHA GLPVHERLRL DAAALAALPP LLDAVCRRQA ELNPRAPRLL RRLEDAARQA RALGAAVEAL LAALGAANRG PRAEPPAATA SAASATGVFP AKVLGLRVCG LYREWLSRTE GDLGQLLPGG SA.

Storage Instruction

Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.

Sample Prep Instruction

It is recommended to add 0.1M Acetate buffer pH-4 to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. For conversion into higher pH value, we recommend intensive dilution by relevant buffer to a concentration of 10?g/ml. In higher concentrations the solubility of this antigen is limited. Protein is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.

References

Not Available
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CTF1, His
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