CSTA His

Alternative Names: Cystatin-A, Cystatin-AS, CSTA, Stefin-A, STF1, STFA.

Cystatin-A, a member of the cystatin superfamily, is an intracellular inhibitor of the cysteine proteinase cathepsin B (CatB). Cysteine protease inhibitor CSTA forms strong complexes with papain and cathepsins B, H, and L. CatB and its inhibitor Cystatin-A play a role in degrading extracellular matrix proteins during tissue remodeling. CSTA, found in high concentrations in epithelial cells, polymorphonuclear leukocytes, and lymphoid tissue, also contributes to epidermal development and maintenance. Stefins, including CSTA, have potential as prognostic and diagnostic tools for cancer.

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  • Sku: PSB-pro-504-5µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human Cystatin-A His Tag is a protein that belongs to the cystatin family, which comprises cysteine protease inhibitors. With a molecular weight of approximately X kDa, this protein is involved in regulating the activity of cysteine proteases, thereby playing a crucial role in various physiological processes. The His tag attached to the protein allows for easy purification and detection in laboratory settings. This recombinant protein is widely used in scientific research to study the mechanisms and functions of cysteine proteases in different biological systems.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
13.1 kDa
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation Cystatin-A (1mg/ml) in20mM Tris-HCl buffer (pH8.0), 1mM DTT and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MIPGGLSEAK PATPEIQEIV DKVKPQLEEK TNETYGKLEA VQYKTQVVAG TNYYIKVRAG DNKYMHLKVF KSLPGQNEDL VLTGYQVDKN KDDELTGF.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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CSTA His

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