CST3

Alternative Names: Cystatin-C, Cystatin-3, Neuroendocrine basic polypeptide, Gamma-trace, Post-gamma-globulin, CST3, MGC117328

Cystatins are a type of cysteine proteinase inhibitors found in plants and animals. They are widely found in tissues and body fluids and can tightly bind to cysteine proteases like cathepsin B, H, L, and S. Cystatin C, a secreted molecule in this family, is important for biochemical, medical, and evolutionary studies. It is elevated in patients with malignant diseases and is a more reliable marker than creatinine for renal function insufficiency. Conversely, low cystatin C levels can lead to the breakdown of elastic laminae, resulting in atherosclerosis and abdominal aortic aneurysm.

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  • Sku: PSB-pro-2601-50µg
  • Vendor: ProSpec-Tany
$330.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Cystatin C is a protein that belongs to the cystatin superfamily, a group of cysteine protease inhibitors. With a molecular weight of approximately 13 kDa, this protein plays a vital role in regulating protease activity and maintaining proteostasis within the body. Recombinant Human Cystatin C is widely used in scientific research and diagnostic applications due to its ability to serve as a reliable biomarker for kidney function and its potential implications in various diseases, including cardiovascular disorders and neurodegenerative conditions.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 98.0 % by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 13.3 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation Cystatin-C is supplied as a 0.2 μm filtered solution containing 20mM Tris-HCl, 50 % glycerol, pH 8.0 and 300mM NaCl.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

SSPGKPPRLV GGPMDASVEE EGVRRALDFA VGEYNKASND MYHSRALQVV RARKQIVAGV NYFLDVELGR TTCTKTQPNL DNCPFHDQPH LKRKAFCSFQ IYAVPWQGTM TLSKSTCQDA.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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CST3
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