CRYGC

Alternative Names: Crystallin, gamma C, CRYG3, Gamma-crystallin 2-1, Gamma-crystallin 3, CCL.

CRYGC is a member of the beta/gamma-crystallin family, which is part of the larger mammalian lens crystallin family. The beta and gamma crystallins are considered a superfamily. Gamma-crystallins are a group of symmetrical, monomeric proteins that lack connecting peptides and terminal extensions. They are regulated differently after early development. There are three pseudogenes (gamma-E, F, G) and four intact gamma-crystallin genes (gamma-A, B, C, D) arranged in a gene cluster in the genome. Gamma-crystallins play a role in cataract formation due to aging or mutations in specific genes. Mutations in CRYGC cause two types of cataracts: cataract Coppock-like (CCL) and cataract autosomal dominant (ADC).

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  • Sku: PSB-pro-1095-5µg
  • Vendor: ProSpec-Tany
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UniProt Listing
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Product Details

Product Description

Recombinant Human Crystallin, Gamma C is a protein that belongs to the crystallin family. With a molecular weight of [insert weight], it plays a significant role in maintaining the transparency and refractive properties of the lens in the human eye. This protein is involved in the formation and organization of lens fibers, contributing to the overall structure and function of the lens. Recombinant Human Crystallin, Gamma C is widely utilized in scientific research and pharmaceutical applications due to its importance in understanding lens development, cataract formation, and potential therapeutic interventions.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 23.5 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The CRYGC solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 200mM NaCl, 2mM DTT and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSHMGKITF YEDRAFQGRS YETTTDCPNL QPYFSRCNSI RVESGCWMLY ERPNYQGQQY LLRRGEYPDY QQWMGLSDSI RSCCLIPQTV SHRLRLYERE DHKGLMMELS EDCPSIQDRF HLSEIRSLHV LEGCWVLYEL PNYRGRQYLL RPQEYRRCQD WGAMDAKAGS LRRVVDLY

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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CRYGC
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