CRYBA4

Alternative Names: Beta-crystallin A4, Beta-A4 crystallin, CRYBA4, MCOPCT4.

Beta-crystallin A4 (CRYBA4) is a key component in the structure of the eye lens. It belongs to the beta/gamma-crystallin family, which is responsible for forming the majority of the eye lens's structure. Beta-crystallins have the ability to form aggregates of different sizes and can either self-associate to form dimers or combine with other beta-crystallins to form heterodimers. The CRYBA4 gene is classified as a beta acidic group member and is part of a gene cluster that includes beta-B1, beta-B2, and beta-B3.

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  • Sku: PSB-hsp-048-5µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

Recombinant Human Crystallin Beta A4 is a protein that belongs to the crystallin family, a group of proteins found in the lens of the eye. With a weight of approximately X kilodaltons (kDa), this protein plays a significant role in maintaining the transparency and refractive properties of the lens. Recombinant Human Crystallin Beta A4 is synthesized using genetic engineering techniques, allowing for its production in large quantities for research and therapeutic purposes. Its precise structure and function make it a valuable tool for studying lens development, cataract formation, and potential treatments for ocular disorders.

Current Lead Time

7-14 Days

Product Specifications

Species
 human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 24.5 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The CRYBA4 protein (1mg/ml) 20mM Tris-HCl buffer (pH8.0), 20% glycerol, 0.1M NaCl and 1mM DTT.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MTLQCTKSAG PWKMVVWDED GFQGRRHEFT AECPSVLELG FETVRSLKVL SGAWVGFEHA GFQGQQYILE RGEYPSWDAW GGNTAYPAER LTSFRPAACA NHRDSRLTIF EQENFLGKKG ELSDDYPSLQ AMGWEGNEVG SFHVHSGAWV CSQFPGYRGF QYVLECDHHS GDYKHFREWG SHAPTFQVQS IRRIQQ.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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CRYBA4
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