CRABP1

Alternative Names: Cellular retinoic acid-binding protein 1, Cellular retinoic acid-binding protein I, CRABP1, CRABP-I, RBP5, CRABP, CRABPI.

CRABP1, a carrier protein belonging to the vitamin A family, plays a crucial role in the differentiation and proliferation processes mediated by retinoic acid. Unlike cellular retinol-binding proteins, CRABP1 selectively binds retinoic acid within the nucleus, potentially facilitating vitamin A-induced differentiation in epithelial tissue. CRABP1 is consistently present in cells and is believed to have different functions compared to its counterpart CRABP2. Its beta-barrel structure enables it to accommodate hydrophobic ligands internally. The loss of CRABP1 function due to hypermethylation of its promoter has been associated with the development of papillary thyroid carcinoma. Additionally, the frequent methylation-induced silencing of CRABP1 is connected to esophageal squamous-cell carcinoma.

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  • Sku: PSB-pro-710-5µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

Recombinant Human Cellular Retinoic Acid Binding Protein 1 (CRABP1) is a protein that belongs to the cellular retinoic acid-binding protein (CRABP) family. With a molecular weight of approximately 15 kDa, CRABP1 plays a significant role in the intracellular transport and metabolism of retinoic acid, a derivative of vitamin A. This protein is involved in regulating gene expression and cellular differentiation processes. Understanding the function and structure of CRABP1 is crucial for comprehending the intricate mechanisms underlying retinoic acid signaling pathways and its impact on various biological processes.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 95.0 % by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 15.5 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The CRABP1 (1mg/ml) protein solution contains 20mM Tris-HCl buffer (pH8.0) and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MPNFAGTWKM RSSENFDELL KALGVNAMLR KVAVAAASKP HVEIRQDGDQ FYIKTSTTVR TTEINFKVGE GFEEETVDGR KCRSLATWEN ENKIHCTQTL LEGDGPKTYW TRELANDELI LTFGADDVVC TRIYVRE.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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CRABP1
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