CPLX1

Alternative Names: CPLX-1, CPXI, CPX-I, CPX1, CPX-1, Synaphin2, Synaphin-2, Complexin-1, Complexin I, CPX I, CPLX1.

CPLX1 is a member of the SNARE family complex binding proteins, which either catalyze or inhibit vesicle exocytosis. It has been observed that CPLX1 decreases Ca2+-triggered fast neurotransmitter release at hippocampal glutamatergic synapses, suggesting that CPLX1 is a positive regulator of transmitter release. On the other hand, CPLX1 inhibits SNARE-mediated liposome and cell fusions in vitro, suggesting that it acts as a fusion clamp of synaptic exocytosis. Therefore, CPLX1 plays a role in regulating the late step of synaptic vesicle exocytosis.

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  • Sku: PSB-pro-645-10µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Complexin-1 is a protein that belongs to the complexin family, which plays a critical role in regulating neurotransmitter release at synapses. With a molecular weight of approximately 17 kilodaltons, this protein is involved in modulating synaptic vesicle fusion and neurotransmitter release by binding to the SNARE complex. Recombinant Human Complexin-1 is widely used in scientific research to study the mechanisms underlying synaptic transmission and to explore potential therapeutic targets for neurological disorders.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 17.1 kDa
Structure Monomer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The CPLX1protein solution contains 20mM Tris-HCl pH-8 and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MEFVMKQALG GATKDMGKML GGDEEKDPDA AKKEEERQEA LRQAEEERKA KYAKMEAERE AVRQGIRDKYGIKKKEEREA EAQAAMEANS EGSLTRPKKA IPPGCGDEVE EEDESILDTV IKYLPGPLQD MLKK.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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CPLX1
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