COX5A

Alternative Names: Cytochrome c oxidase subunit 5A, Cytochrome c oxidase polypeptide Va, COX5A, VA, COX, COX-VA, mitochondrial.

Cytochrome C Oxidase Subunit Va (COX5A) belongs to the cytochrome c oxidase subunit 5A family. It is part of the COX complex, which is responsible for transferring electrons from reduced Cytochrome C to oxygen in the mitochondrial respiratory chain. The COX complex consists of three catalytic subunits and multiple structural subunits. The catalytic subunits are encoded by mitochondrial genes, while the structural subunits are encoded by nuclear genes. The mitochondrially-encoded subunits are involved in electron transfer, while the nuclear-encoded subunits regulate and assemble the complex. COX5A is the heme A-containing chain of Cytochrome C Oxidase, serving as the terminal oxidase in mitochondrial electron transport.

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  • Sku: PSB-pro-1331-5µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Cytochrome C Oxidase Subunit Va is a protein encoded by the COX5A gene in humans. Belonging to the cytochrome c oxidase family, this subunit plays a crucial role in the electron transport chain, specifically in the final step of aerobic respiration. With a molecular weight of approximately 9.6 kilodaltons, it is involved in the transfer of electrons from cytochrome c to the catalytic subunits of cytochrome c oxidase, facilitating the conversion of molecular oxygen to water. This recombinant protein is commonly used in research and pharmaceutical applications to study mitochondrial function and energy metabolism.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 14.9 kDa
Structure Heteromer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation COX5A protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 10% glycerol and 2mM DTT.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSSHGSQET DEEFDARWVT YFNKPDIDAW ELRKGINTLV TYDMVPEPKI IDAALRACRR LNDFASTVRI LEVVKDKAGP HKEIYPYVIQ ELRPTLNELG ISTPEELGLD KV.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
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References

Not Available
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COX5A
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