COMP

Alternative Names: Thrombospondin-5, Cartilage Oligomeric Matrix Protein (pseudoachondroplasia epiphyseal dysplasia 1 multiple), MED, THBS5, TSP5, EDM1, PSACH, EPD1

COMP is a non-collagenous glycoprotein belonging to the thrombospondin family of extracellular proteins. It is a calcium-binding protein with a large molecular weight and is found in the extracellular matrix of certain cartilage types. While it is primarily derived from cartilage, COMP is also present in other tissues like synovium and tendon. The intact form of COMP consists of five equal subunits, and the carboxy-terminal globular domain of native COMP binds to specific collagen types. COMP plays a crucial role in maintaining the properties and integrity of the collagen network. Additionally, it acts as a storage and delivery system for hydrophobic cell-signaling molecules like vitamin D. Mutations in the COMP gene lead to conditions such as Pseudoachondroplasia and certain forms of multiple epiphyseal dysplasia, highlighting the importance of normal COMP development and function.

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  • Sku: PSB-pro-2727-2µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Cartilage Oligomeric Matrix Protein (rhCOMP) is a protein that belongs to the family of extracellular matrix (ECM) proteins. With a weight of approximately 524 kDa, rhCOMP plays a significant role in maintaining the structural integrity and functionality of cartilage tissues. It is involved in various biological processes, including cell adhesion, proliferation, and differentiation, making it a crucial component in the development and maintenance of healthy cartilage. By providing a dry, scientific voice, this description aims to provide concise and factual information about rhCOMP for SEO purposes.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System HEK 293
Purity 85.0 by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) No
Molecular Weight
 82.4 kDa
Structure Monomer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The COMP solution (0. 5mg/1ml) contains phosphate buffered saline (pH7.4) and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

ADPDAHSLWY NFTIIHLPRH GQQWCEVQSQ VDQKNFLSYD CGSDKVLSMG HLEEQLYATD AWGKQLEMLR EVGQRLRLEL ADTELEDFTP SGPLTLQVRM SCECEADGYI RGSWQFSFDG RKFLLFDSNN RKWTVVHAGA RRMKEKWEKD SGLTTFFKMV SMRDCKSWLR DFLMHRKKRL EPTAPPTMAP GLEPKSCDKT HTCPPCPAPE LLGGPSVFLF PPKPKDTLMI SRTPEVTCVV VDVSHEDPEV KFNWYVDGVE VHNAKTKPRE EQYNSTYRVV SVLTVLHQDW LNGKEYKCKV SNKALPAPIE KTISKAKGQP REPQVYTLPP SRDELTKNQV SLTCLVKGFY PSDIAVEWES NGQPENNYKT TPPVLDSDGS FFLYSKLTVD KSRWQQGNVF SCSVMHEALH NHYTQKSLSL SPGKHHHHHH

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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COMP
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