COMMD1

Alternative Names: Copper Metabolism Domain Containing 1, COMMD1, C2orf5, MGC27155, MURR1.

COMMD1 inhibits TNF-induced NFκB p50 and promotes biliary copper excretion in liver cells. It is highly expressed in liver tissue and less so in lung, heart, kidney, and brain tissue. COMMD1 directly interacts with COMMD6 and ATP7B, and indirectly interacts with IκB-β and COMMD7.

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  • Sku: PSB-pro-862-2µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human Copper Metabolism Domain Containing 1 (RHCO1) is a protein that plays a significant role in copper homeostasis within the human body. Belonging to the copper metabolism protein family, RHCO1 is involved in the transportation and regulation of copper ions, which are essential for various physiological processes. With a molecular weight of approximately X kDa, RHCO1 is a crucial component in maintaining copper balance and facilitating its utilization in enzymatic reactions. This protein's function and structural characteristics make it a subject of interest in understanding copper-related disorders and potential therapeutic interventions.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation COMMD1 Human solution containing 20mM Tris pH-8, 0.1M NaCl & 20% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MAAGELEGGK PLSGLLNALA QDTFHGYPGI TEELLRSQLY PEVPPEEFRP FLAKMRGILK SIASADMDFN QLEAFLTAQT KKQGGITSDQ AAVISKFWKS HKTKIRESLM NQSRWNSGLR GLSWRVDGKS QSRHSAQIHT PVAIIELELG KYGQESEFLC LEFDEVKVNQ ILKTLSEVEE SISTLISQPN.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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COMMD1

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