Collagen-II

Alternative Names: Not Available

Collagen is a fibrous protein found in the extracellular matrix that enhances tissue strength and structural stability. It has been widely used in medical, pharmaceutical, and consumer products for more than a century due to its abundance and low cost from animal remains. However, most collagen formulations are not thoroughly purified, which can lead to inflammatory reactions in some users. Additionally, concerns have emerged about the contamination of bovine products with agents causing diseases like mad cow disease and Creutzfeldt-Jakob Disease. Animal collagens undergo continuous modifications in the extracellular space, resulting in significant variability between different collagen sources. This variability makes it challenging to analyze and standardize collagen derived from tissues. Moreover, using animal-derived collagen in products can potentially trigger harmful immune responses in humans and pose the risk of viral or prion contamination, which can be life-threatening. On the other hand, recombinant collagens are almost identical to natural collagen, significantly reducing the risks of inflammation, immune responses, and diseases typically associated with animal-sourced collagen.

  •
  • Sku: PSB-pro-2732-10µg
  • Vendor: ProSpec-Tany
$200.00 USD
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

Human Collagen-II is a vital protein that plays a significant role in maintaining the structural integrity of various tissues in the body. Belonging to the collagen family, it is a fibrous protein primarily found in cartilage, providing strength, flexibility, and support to this connective tissue. With a weight of approximately 300 kDa, Human Collagen-II contributes to the maintenance and functionality of joints, ensuring their smooth movement and cushioning. This collagen variant is crucial for the overall stability and proper functioning of cartilage, making it an essential component in the musculoskeletal system.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System Human cartilage
Purity 95 by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) No
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation Collagen-I was lyophilized without additives.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Storage Instruction

Lyophilized Collagen-II although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution Collagen-II should be stored at 4C between 2-7 days and for future use below -18C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to add 0.5 M acetic acid, pH 2.5 to prepare a working stock solution not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available
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Collagen-II
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