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CNTF, His Active

Alternative Names: Ciliary neurotrophic factor, HCNTF, CNTF

CNTF is a polypeptide hormone primarily active in the nervous system, where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. It serves as a survival factor for neurons and oligodendrocytes, potentially reducing tissue destruction during inflammation attacks. Mutations in CNTF can lead to a deficiency in ciliary neurotrophic factor, although this does not directly cause neurological diseases. CNTF also co-transcribes with the ZFP91 gene, resulting in a transcript that includes the complete coding region for the zinc finger protein but not for ciliary neurotrophic factor. Additionally, CNTF has been shown to prevent motor axon degeneration following axotomy.

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  • Sku: PSB-cyt-909-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Ciliary Neurotrophic Factor, His Tag Active is a protein belonging to the neurotrophic factor family. It plays a key role in promoting the survival and differentiation of various neuronal cell types. With a molecular weight of approximately 22 kDa, this protein is commonly used in research settings to study neuroprotection and neuroregeneration mechanisms. The His tag allows for easy purification and detection of the protein, making it a valuable tool for studying the effects of ciliary neurotrophic factor on neuronal cells.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Measured in a cell proliferation assay using TF-1 human erythroleukemic cell. The ED50 for this effects is less or equal to 1 ug/ml.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation CNTF protein solution (1mg/ml) containing 20 mM Tris-HCl buffer (pH 8.5), 1 mM DTT,30% Glycerol and 0.2M NaCl.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MAFTEHSPLT PHRRDLCSRS IWLARKIRSD LTALTESYVK HQGLNKNINL DSADGMPVAS TDQWSELTEA ERLQENLQAY RTFHVLLARL LEDQQVHFTP TEGDFHQAIH TLLLQVAAFA YQIEELMILL EYKIPRNEAD GMPINVGDGG LFEKKLWGLK VLQELSQWTV RSIHDLRFIS SHQTGIPARG SHYIANNKKM.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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